Abstract

Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30 times the osmolality of healthy vaginal fluid. Hyperosmolal formulations have been shown to cause marked toxicity to human colorectal epithelia in vivo, and significantly increase vaginal transmission of genital herpes infections in the mouse/HSV model. They also cause toxicity to explants of vaginal epithelia, to cultured vaginal epithelial cells, and increase susceptibility to HIV in target cells in cell cultures. Here, we report that the osmolality of healthy vaginal fluid is 370 ± 40 mOsm/Kg in women with Nugent scores 0–3, and that a well-characterized three-dimensional human vaginal epithelium tissue model demonstrated that vaginal lubricants with osmolality greater than 4 times that of vaginal fluid (>1500 mOsm/Kg) markedly reduce epithelial barrier properties and showed damage in tissue structure. Four out of four such lubricants caused disruption in the parabasal and basal layers of cells as observed by histological analysis and reduced barrier integrity as measured by trans-epithelial electrical resistance (TEER). No epithelial damage to these layers was observed for hypo- and iso-osmolal lubricants with osmolality of <400 mOsm/Kg. The results confirm extensive reports of safety concerns of hyperosmolal lubricants and suggest the usefulness of reconstructed in vitro vaginal tissue models for assessing safety of lubricants in the absence of direct clinical tests in humans.

Have you forgotten. ‘/s’ ?

Yes!

My Xiaomi Redmi 11 keeps telling me the Calculator can’t use the network (why?) and keeps asking me to accept the privacy policy.

Also the app wallpaper - the one that changes the locked screen background image (important complex stuff /s) - also keeps asking me to accept the privacy policy.

And, as far as my reading of the policy goes, these privacy policies are just the one, it’s not a different one for each app.

EDIT: I think Musk went of the rails after he got COVID, I speculate. It’s my own take on creating a conspiracy theory.

Musk see!

Keeping things sterile is very labour and energy intensive, even in the Pharma industry, where the profit margins are orders of magnitude above what you can do in the food industry.

Look this will sound harsh, but it’s not, really.

Your reasoning is good if you compare it to an hypothesis a student of Pasteur or Koch could have thought of 150 yrs ago.

Thus I have to ask you, why did you think you have a good take on this?

This comment, above, does not provide any context to the news linked.

Please,

discussing a complex geopolitical situation

Is not

telling their users to be nice to others and not break the rules of other instances

You are not being consistent.

Also, an admin detailing how to think about a complex geopolitical situation is not discussing.

Thanks for offering your perspective. Maybe I’m too cynical. Or maybe I’m reading to much into the Russia-Ukraine-Nato thing.

In any case, at current information, I can both accept the defederation, or just teaching people that they can choose and block specific users and communities.

Maybe I’m misunderstanding all the Russia-Ukraine-NATO section.

Thanks for the answer but I can only understand your first sentence. After that I have no clue about what you mean .

From reading that thread it is not just a socialist instance.

They are instructing their members on how to relate to others, how to react to outsiders comments in their communities, and how to protect themselves from outsiders opinions. To me that sounds like cult level brainwashing techniques.

Another word that comes to mind is brigading.

The Hexbear thread on federation: https://www.hexbear.net/post/280770 – read it yourself.

To me it reads like a plan to increase their reach with preventive instructions on how to avoid being ‘influenced’ by outsiders’ opinions.

My guesstimation is that it is a disinformation machine based on useful idiots.