I just use the Firefox flatpak from flathub.

Definitely a strange choice for a distro that pushes flatpak to not use it for the browser by default.

See https://wiki.winehq.org/FAQ#How_good_is_Wine_at_sandboxing_Windows_apps.3F from their FAQ

Are you referring to the ones with excessive sandbox permissions that flathub allows by default? Or is this something else?

Since drivers are so specifc, people’s anecdotal experiences with having to install them is never going to be shared.

IE, I had to install a wired NIC driver just last month on a fresh Windows 10 22H2 for a Dell laptop that was no more than a few years old.