So much medical misinformation in this thread but it looks like there’s some merit to acetaminophen tolerance.

Less so NSAIDs. They definitely need more studies that take human populations into account because there aren’t any I could find that weren’t in rats.

Acetaminophen resistance:

https://pubmed.ncbi.nlm.nih.gov/18468992/

NSAID:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341275/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756434/